Leucocyte Rolling

《英文msh詞典》Leucocyte Rolling
[入口詞] Leucocyte Rolling
[主題詞] Leukocyte Rolling
[英文釋義] Movement of tethered,spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte.The rolling leukocyte then becomes activated by CHEMOKINES,flattens out,and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas,Cellular and Molecular Immunology,3rd ed)